Literature of Intrahepatic Cholestasis of Pregnancy

Literature for Intrahepatic Cholestasis of Pregnancy ICP

Published Literature of Intrahepatic Cholestasis of Pregnancy

Symptoms

Berg B, Helm G, Petersohn L, Tryding N: Cholestasis of pregnancy. Clinical and laboratory studies. Acta Obstet Gynecol Scand 1986;65:107-113. [Pub Med]

Kenyon et al. Pruritus may precede abnormal liver function tests in pregnant women with obstetric cholestasis: a longitudinal analysis. Br J Obstet Gynaec 2001;108:1190-1192. [Pub Med]

Kremer AE, Martens JJWW, Kulik W, et al: Lysophosphatidic acid is a potential mediator of cholestatic pruritis. Gastroeneterology 2010;139:1008-1018. [Pub Med]

Reyes et al. Steatorrhea in patients with intrahepatic cholestasis of pregnancy. Gastroenterology 1987;93:584-590. [Pub Med]

Etiology

Hirvioja ML, Kivinen S: Inheritance of intrahepatic cholestasis of pregnancy in one kindred. Clinical Genetics 1993;43:315- 317 [Pub Med]

Dixon PH, Wadsworth CA, Chambers J, et al: A Comprehensive Analysis of Common Genetic Variation Around Six Candidate Loci for Intrahepatic Cholestasis of Pregnancy. Am J Gastro 2014;109:76-84 [Pub Med]

Savander M, Rapponen A, Avela K, et al: Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy. Gut 2003;52:1025-1029 [Pub Med]

Keitel V, Vogt C, Haussinger D, Kubitz R: Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. Gastroenterology 2006;131:624-629. [Pub Med]

Johnston RC, Stephenson ML, Nageotte MP: Novel heterozygous ABCB4 gene mutation causing recurrent first-trimester intrahepatic cholestasis of pregnancy. J Perinat 2014;34:711-712 [Pub Med]

Drug- and Estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver [Pub Med]

Bacq Y, Sapey T, Brechot MC, et al: Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatology 1997;26:358-364 [Pub Med]

Bacq Y, Myara A, Brechot MC, et al: Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy. Journal of Hepatology 1995;22:66-70 [Pub Med]

Abu-Hayyeh S, Ovadia C, Lieu T, et al: Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritis gravidarum. Hepatology, 2015;doi:10.1002/hep.28265 [Pub Med]

Pacella G, Salsi G, Archangeli T, et al: The impact of assisted reproductive technology and chorionicity in twin pregnancies complicated by obstetric cholestasis. J Matern Fetal Neonatal Med, 2015; doi:10.3109/14767058.2015.1051954 [Pub Med]

Gonzalez MC, Reyes J, Arrese M, et al: Intrahepatic cholestasis of preganancy in twin pregnancies. J Hepatology 1989;9:84-90 [Pub Med]

Reyes H, Maez ME, Gonzalez MC, et al: Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile. J Hepatology 2000;32:542-549 [Pub Med]

Floreani A, Caroli D, Lazzari R et al: Intrahepatic cholestasis of pregnancy: new insights into its pathogenesis. J Matern Fetal Neonatal Med 2013;26(14):1410-1415. [Pub Med]

Diagnosis

Lee RH, Ouzounian JG, Goodwin TM, et al: Bile acid concentration reference ranges in a pregnant Latina population. Am J Perinatology 2013;30(5):389-393. [Pub Med]

Society for Maternal-Fetal Medicine (SMFM), Lee RH, Pettker CM. Society for Maternal-Fetal Medicine (SMFM) Consult Series #53: Intrahepatic Cholestasis of Pregnancy. Am J Obstet Gynecol. 2020 Nov 13:S0002-9378(20)31284-9. doi: 10.1016/j.ajog.2020.11.002. Epub ahead of print. PMID: 33197417. [smfm.org]

Wongjarupong N, Bharmal S, Lim N. Never Too Soon: An Unusual Case of Intrahepatic Cholestasis of Pregnancy at Five Weeks Gestation. Cureus. 2020 Sep 19;12(9):e10540. doi: 10.7759/cureus.10540. PMID: 33094079; PMCID: PMC7574978. [Pub Med]

Mitchell AL, Ovadia C, Syngelaki A, Souretis K, Martineau M, Girling J, Vasavan T, Fan HM, Seed PT, Chambers J, Walters JRF, Nicolaides K, Williamson C. Re-evaluating diagnostic thresholds for intrahepatic cholestasis of pregnancy: case-control and cohort study. BJOG. 2021 Feb 15. doi: 10.1111/1471-0528.16669. Epub ahead of print. PMID: 33586324. [Pub Med]

Maternal complications

Reid R, Ivey KJ, Rencoret RH, Storey B: Fetal complications of obstetric cholestasis. Br Medical J 1976;1:870-872. [Pub Med]

DeLeon A, De Oliveira GS, Kalayil M et al: The incidence of coagulopathy in pregnant patients with intrahepatic cholestasis: should we delay or avoid neuraxial analgesia? J Clinical Anesthesia 2014;26(8):623-627. [Pub Med]

Ranier PP, Primessniq U, Harencamp S, et al: Bile acids induce arrhythmias in human atrial myocardium–implications for altered serum bile acid composition in patients with atrial fibrillation. Heart 2013;99(22):1685-1692. [Pub Med]

Biberoglu EH, Kirbas A, Kirbas O, et al: Prediction of cardiovascular risk by by electrocardiographic changes in women with intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med 2015;28(18):2239-2243. [Pub Med]

Fetal complications

Wikstrom SE, Marschall HU, Ludvigsson JF, Stephansson O: Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study. Br J Obstet Gynaec 2013;120:717-723. [Pub Med]

Fisk NM, Storey GN: Fetal outcome in obstetric cholestasis. Br J Obstet Gynaec 1988;95:1137-1143. [Pub Med]

Davies MH, Silva RCMA, Jones SR et al: Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid. Gut 1995;37:580-584. [Pub Med]

Glantz A, Marschall HU, Mattsson LA: Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology 2004;40:467-474. [Pub Med]

Recoret R, Aste H: Jaundice during pregnancy. Med J Australia. 1973;1:167-169. [Pub Med]

Madazli R, Yuksel MA, Oncul M: Pregnancy outcomes and prognostic factors in patients with intrahepatic cholestasis of pregnancy. J Obstet Gynaec. 2015;35(4). [Pub Med]

Geenes V, Chappell, LC, Seed PT, et al: Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Heptatology. 2014;59(4):1482-1491. [Pub Med]

Brouwers L, Koster MPH, Page-Christiaens GCML, et al: Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acids. Am J Obstet Gynec 2015;212(1);100.e1-100.e7. [Pub Med]

Additional comments by the author (http://www.ajog.org/article/S0002-9378(15)00322-1/fulltext)

Germain AM, Kato S, Carvajal JA, et al: Bile acids increase response and expression of human myometrial oxytocin receptor. Am J of Obstet Gynecol 2003;189:577-582. [Pub Med]

Kawakita T, Parikh LI, Ramsey PS, et al: Predictors of adverse neonatal outcomes in intrahepatic cholestasis of pregnancy. Am J Obstet Gynec. 2015;213(4):570.e1-570.e2. [Pub Med]

Rook M, Vargas J, Caughey A, et al: Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort. PLoS ONE 2012;7: e28343. [Pub Med]

Zecca E, De Luca D, Marras M, et al: Intrahepatic cholestasis of pregnancy and neonatal respiratory distress syndrome. Pediatrics 2006;117:1669-1673. [Pub Med]

Kowalski A, Janosz-Galdys I, Olejek A, et al: Correlation between serum levels of bile acids in pregnant women with intrahepatic cholestasis of pregnancy and condition of their newborns. Ginekol Pol 2014;85(2):101-104. [Pub Med]

Zecca E, De Luca D, Barbato, G, et al: Predicting respiratory distress syndrome in neonates from mothers with intrahepatic cholestasis of pregnancy. Early Human Development 2008;84:337-341. [Pub Med]

Oztekin D, Aydal I, Oztekin O, et al: Predicting fetal asphyxia in intrahepatic cholestasis of pregnancy. Archives Gynecol Obstet 2009;280:975-979. [Pub Med]

Zecca E, Costa S, Lauriola V, et al: Bile acid pneumonia: A “new” form of neonatal respiratory distress syndrome? Pediatrics 2003;114:269-272. [Pub Med]

Zecca E, De Luca D, Baroni S, et al: Bile acid-induced injury in newborn infants: a bronchoalveolar study. Pediatrics 2008;121:e146-149. [Pub Med]

Herraez E, Lozano E, Poli E, et al: Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis. J Molec Medicine 2014;92(4):359-372. [Pub Med]

Shaw D, Frohlich J, Wittmann BA, Willms M: A prospective study of 18 patients with cholestasis of pregnancy. Am J Obstet Gynecol 1982;142:621-625. [Pub Med]

Sheibani L, Urinak ABS, Lee RH et al: Intrahepatic cholestasis of pregnancy: the effect of bile acids on fetal heart rate tracings. Obstet Gynec 2014;123:78S-79S. [Research Gate]

Williamson C, Miragoli M, Kadir SSA et al: Bile acid signaling in fetal tissues: implications for intrahepatic cholestasis of pregnancy. Digestive Diseases 2011;29:58-61. [Pub Med]

Sepulveda WH, Gonzalez C, Cruz MA, Rudolph MI et al: Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. Eur J Obstet Gynec Reprod Biol 1991;42(3):211-215. [Pub Med]

Shemer EW, Thorsell M, Ostlund E, et al: Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy. Placenta 2012;33:914-918. [Pub Med]

Geenes VL, Lim YH, Bowman N, et al: A placental phenotype for intrahepatic cholestasis of pregnancy. Placenta 2011;32: 1026-1032. [Pub Med]

Oztas E, Ozler S, Ersoy AO et al: Placental ADAMTS-12 levels in the pathogenesis of preeclampsia and intrahepatic cholestasis of pregnancy. Reproductive Sciences 2015;doi:10.1177/193371 115604730 [Pub Med]

Martineau M, Papcleovoulou G, Abu-Hayyeh SA et al: Cholestatic pregnancy is associated with reduced placental 11βHSD2 expression. Placenta 2014;35(1):37-43. [Pub Med]

Ovadia C, et al. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet. 2019 Mar 2;393(10174):899-909. doi: 10.1016/S0140-6736(18)31877-4. Epub 2019 Feb 14. Erratum in: Lancet. 2019 Mar 16;393(10176):1100. PMID: 30773280; PMCID: PMC6396441. [Pub Med]

Sudden fetal death despite reassuring CTG

Lee RH, Incerpi MH, Miller D, et al: Sudden fetal death in intrahepatic cholestasis of pregnancy. Obstet Gynecol 2009;113:528-531. [Pub Med]

Laatikainen T, Tulenheimo A: Maternal serum bile acid levels and fetal distress in cholestasis of pregnancy. Internat J Gynaecol Obstet 1984;22:91-94. [Pub Med]

Alsulyman OM, Ouszounian JG, Ames-Castro M, Goodwin TM: Intrahepatic cholestasis of pregnancy: perinatal outcome associated with expectant management. Am J Obstet Gynecol 1996;175:957-960. [Pub Med]

Sentilhes L, Verspyck E, Pia P, Marpeau L: Fetal death in a patient with intrahepatic cholestasis of pregnancy. Obstet Gynecol 2006;107:458-460. [Pub Med]

Management

Chappell LC, et al. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy. Lancet 2019; 394(10201):849-860. doi:https://doi.org/10.1016/S0140-6736(19)31270-X [Pub Med]

Bacq Y, Sentilhes L, Reyes HB, et al: Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis. Gastroenterology 2012;143:1492-1501. [Pub Med]

Lee RH, Kwok KM, Ingles S, et al: Pregnancy outcomes in an era of aggressive management for intrahepatic cholestasis of pregnancy. Am J Perinatology 2008;25:341-345. [Pub Med]

Roncaglia N, Arreghini A, Locatelli A, et al: Obstetric cholestasis: outcome with active management. Eur J Obstet Gynecol Reprod Biol. 2002;100(2):167-170. [Pub Med]

Mays JK: The active management of intrahepatic cholestasis of pregnancy. Current Opinion Obstet Gynecol 2010;22:100-108. [Pub Med]

Henry A, Welsh AW: Monitoring intrahepatic cholestasis of pregnancy using the fetal myocardial performance index: a cohort study. Ultrasound Obstet Gynecol 2015;46:571-578. [Pub Med]

Carey E, White P: Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby. Evid Based Med 2013;18(6):e55. [Pub Med]

Grand’Maison S, Durand M, Mohone M: The effects of Ursodeoxycholic acid treatment for intrahepatic cholestasis of pregnancy on maternal and fetal outcomes: a meta-analysis including non-randomized studies. J Obstet Gynaec Can 2014;36(7):632-641. [Pub Med]

Serrano MA, Brites D, Larena MG, et al: Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta. J Hepatology 1998;28:829-839. [Pub Med]

Geenes V, Lovgren-Sandblom A, Benthin L, et al: The reversed feto-maternal bile acid gradient in intrahepatic cholestasis of pregnancy is corrected by ursodeoxycholic acid. Plos One 2014;9(1):e83828. [Pub Med]

Azzaroli F, Raspanti ME, Simoni P, et al: High doses of ursodeoxycholic acid up-regulate the expression of placental breast cancer resistance protein in patients affected by intrahepatic cholestasis of pregnancy. Plos One 2013;8:e64101. [Pub Med]

Estiu MC, Monte MJ, Rivas L: Effect of ursodeoxycholic acid on the altered progesterone and bile acid homeostasis in the mother-placenta-foetus trio during cholestasis of pregnancy. Br J Clinical Pharm 2015;79(2):316-329. [Pub Med]

Paumgartner G, Beuers U: Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology 2002;36:525-531. [Pub Med]

Geenes V, Chambers J, Khurana R: Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy. Eur J Obstet Gynecol Reprod Biol 2015;189:59-63. [Pub Med]

Nicastri PL, Diaferia A, Tartagni M, et al: A randomized placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. Br J Obstet Gynaecol 1998;105(11):1205-1207. [Pub Med]

Heikkinen J, Maentausta O, Ylostalo P, et al: Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. Eur J Obstet Gynec Reprod Biol 1982;14:153-162. [Pub Med]

Davies MH, Silva RCMA, Jones SR et al: Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid. Gut 1995;37:580-584. [Pub Med]

Puljic A, Kim E, Page J, et al: The risk of infant and fetal death by each additional week of expectant management in intrahepatic choelstasis of pregnancy by gestational age. Am J Obstet Gynecol 2015;212(5):667.e1-5. [Pub Med]

Lo JO, Shaffer BL, Allen AJ, et al: Intrahepatic cholestasis of pregnancy and timing of delivery. J Matern Fetal Neonatal Med 2015;28(18):2254-2258. [Pub Med]

Liu X, Landon MB, Chen Y, and Cheng W: Perinatal outcomes with intrahepatic cholestasis of pregnancy in twin pregnancies. J Matern Fetal Neonatal Med 2015;doi:10.3109/14767058.2015.1079612. [Pub Med]

Bull L,Vargas J: Serum bile acids in intrahepatic cholestasis of pregnancy: not just a diagnostic test. Hepatology 2014;59(4):1220-1222. [Pub Med]

Ursodiol-Ovadia-2021URSO / UDCA for intrahepatic cholestasis of pregnancy decreased certain adverse outcomes in pregnant women with ICP.

ACOG monitoring guidelines ACOG new recommendations for fetal monitoring during ICP pregnancies

Concurrent complications

Martineau M, Raker C, Powrie R, Williamson C: Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes. Eur J Obstet Gynecol Reprod Biol 2014;176:80-85. [Pub Med]

Raz Y, Lavie A, Vered Y, et al: Severe intrahepatic cholestasis of pregnancy is a risk factor for preeclampsia in singleton and twin pregnancies. Am J Obstet Gynecol 2015;213(3)395.e1-395.e8 [Pub Med]

Follow up care

Aytac S, Kargili A, Turaky C: A prolonged gestational intrahepatic cholestasis: a case report. Turk J Gastroenterology 2006;17:206-208. [Pub Med]

Hardikar W, Kansal S, Elferink RPJO, Angus P: Intrahepatic cholestasis of pregnancy: when should you look further? World J Gastroent 2009;15:1126-1129. [Pub Med]

Ropponen A, Sund R, Riikonen S, et al: Intrahepatic Cholestasis of Pregnancy as an Indicator of Liver and Biliary Diseases: a Population-Based Study. Hepatology 2006;43:723-729. [Pub Med]

Serge E: Intrahepatic cholestasis of pregnancy: A risk factor for cancer, autoimmune and cardiovascular disease? Clinical Research Hep Gastro 2015;doi:10.1016/j.clinre.2015.09.003 [Pub Med]

Papacleovoulou G, Abu-Hayyeh S, Nikolopoulou E, et al: Maternal cholestasis during pregnancy programs metabolic disease in offspring. J Clinic Invest 2013;123(7):3172-3181. [Pub Med]

Vimpeli T, Turunen K, Helander K, et al: Mother’s intrahepatic cholestasis does not affect her daughter’s health. Health 2013;5(6A):28-33. [SCRIP]

Hamalainen S, Turunen K, Kosunen E, et al: Men’s health is not affected by their mother’s intrahepatic cholestasis of pregnancy. Am J Men’s Health 2015;pii:1557988315584795. [Pub Med]